Rotator cuff pain can be debilitating. Not only does it affect the way you're able to maneuver throughout the day in terms of your mobility, but it can even affect how well you're able to rest at night. Finding a solution to the discomfort is mission-critical. A lesser-known treatment option, known as prolotherapy, might be just the solution you've been seeking. Prolotherapy Prolotherapy is a reconstructive and regenerative joint injection that is intended to stimulate healing and injury repair to the connective tissue, tendons, and joints affected.